Awesome List Updates on Aug 27, 2025

9 awesome lists updated today.

1. Awesome Elixir

Roommate (⭐14) - 3D level builder tool with focus on creating indoors environment and automation.

cgen (⭐0) - Generate shell completions for Fish, Bash, and ZSH and man-pages from a single YAML file. No more hand-writing separate completion files for every shell.

Evolution-inspired engineering of nonribosomal peptide synthetases - Science, 2024. [All Versions]. Many clinically used drugs are derived from natural microbial products that are assembled in a stepwise fashion by the condensation of amino acids or acyl groups. Using insights from evolutionary analysis, two independent groups now show that the cumbersome enzyme complexes that produce these molecules can be pieced together to create new products on demand---if one knows the right spot for joining the pieces. Working with nonribosomal peptide synthetases, Bozhüyük et al. developed an approach called XUT (“exchange unit between T domains”) and demonstrated the production of a proteasome inhibitor by an enzyme complex containing fragments of five separate systems. Mabesoone et al. worked with polyketide synthases, demonstrating facile deletion and insertion of conceptually similar exchange units, producing a large number of related polyketide products with diverse modifications. These approaches are an important step forward for rational engineering of large enzyme complexes for small-molecule drug discovery and production.

MathFlow (⭐4) - C# math expression library with symbolic computation (differentiation, simplification, equation solving)

Agenta - Open-source LLMOps platform for prompt management, LLM evaluation, and observability. Build, evaluate, and monitor production-grade LLM applications. #opensource (⭐3.1k)

Alternative frontends/portals to discover/filter awesome-selfhosted apps: awweso.me | awesome-web.theravenhub

RepoFlow - A simple and easy-to-use package management platform with Docker support alongside other formats like PyPI, Maven, npm, and Helm. Includes smart search, built-in Docker image scanning, and a great free option for both self-hosted and cloud use.